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Xmrv and breast cancer

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A retrovirus that has been implicated in prostate cancer has now been found in the blood of patients with chronic fatigue syndrome. What is this virus and where did it come from? The etiology of the disease is unknown, although several viruses have been suggested to be involved, including enteroviruses and herpesviruses. The retrovirus XMRV xenotropic Moloney murine leukemia virus-related virus was recently identified in the tumor tissue of individuals with prostate cancer.
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Xenotropic murine leukemia virus-related virus may not be associated with human prostate cancer

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The human retrovirus XMRV in prostate cancer and chronic fatigue syndrome | Nature Reviews Urology

Xenotropic murine leukemia-related retrovirus XMRV is a recently discovered retrovirus that has been linked to human prostate cancer and chronic fatigue syndrome CFS. Both diseases affect a large fraction of the world population, with prostate cancer affecting one in six men, and CFS affecting an estimated 0. Forty-five compounds, including twenty-eight drugs approved for use in humans, were evaluated against XMRV replication in vitro. We found that the retroviral integrase inhibitor, raltegravir, was potent and selective against XMRV at submicromolar concentrations, in MCF-7 and LNCaP cells, a breast cancer and prostate cancer cell line, respectively. When combined, these drugs displayed mostly synergistic effects against this virus, suggesting that combination therapy may delay or prevent the selection of resistant viruses.
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New study confirms erroneous link between XMRV virus, prostate cancer

The aetiology of breast cancer remains elusive. A viral aetiology has been proposed, but to date no virus has been conclusively demonstrated to be involved. Recently, two new viruses, namely Merkel cell polyomavirus MCV and xenotropic murine leukaemia virus-related virus XMRV have been identified and implicated in the pathogenesis of Merkel cell carcinoma MCC and familial form of prostate cancer, respectively. Samples consisted of both malignant and non-malignant tissues. What role these viruses have in the pathogenesis of MCC and prostate carcinomas remains to be demonstrated.
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Researchers investigating UK samples have found no association between the controversial xenotropic murine leukaemia virus-related virus XMRV and chronic fatigue syndrome CFS. Their study, published in BioMed Central's open access journal Retrovirology , calls into question a potential link described late last year by an American research team. We are confident that, although we were unable to replicate the detection, our PCR assay is more sensitive than the earlier method and possessed the necessary sensitivity to detect XMRV had it been present.
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