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Cah and vaginal development

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Added: 03.11.2019
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The two most serious neonatal consequences of hydroxylase deficiency occur when there is minimal measurable hydroxylase activity from prenatal life: life-threatening salt-wasting crises in the first month of life for XX and XY infants alike and severe virilization of female infants. The excessive amounts of adrenal testosterone produce little effect on the genitalia of male infants with severe CAH. If a male infant with CAH is not detected by newborn screening , he will appear healthy and normal and be quickly discharged home to his family. However, the lack of aldosterone results in a high rate of sodium loss in the urine. With this rate of salt loss, the infant cannot maintain blood volume, and hyponatremic dehydration begins to develop by the end of the first week of life.
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Endometrial Cancer Risk Factors

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Congenital Adrenal Hyperplasia | Causes and Treatment | Patient

Back to Health A to Z. Differences in sex development DSD is a group of rare conditions involving genes, hormones and reproductive organs, including genitals. Some adults and young people with DSD prefer to use the term intersex. You or your child may have sex chromosomes bundles of genes usually associated with being female XX chromosomes or usually associated with being male XY chromosomes , but reproductive organs and genitals that may look different from usual. This happens because of a difference with your genes or how you respond to the sex hormones in your body, or both. It can be inherited, but there is often no clear reason why it happens. Some people have XX usual female chromosomes with ovaries and a womb, but their genitals may not look the same as many females.
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Female Genital Abnormalities

Index of Core Concept Chapters. About Core Concepts. S ex determination and sex differentiation can be divided into a chromosomal sex or karyotype 46 XX, 46 XY, or variants , b gonadal sex presence of a testis or ovary and c phenotypic sex external genitalia and internal structures. Figure Sexual development.
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Medically reviewed by Drugs. Last updated on Oct 9, Congenital adrenal hyperplasia CAH is a group of inherited genetic disorders that affect the adrenal glands, a pair of walnut-sized organs above your kidneys. A person with CAH lacks one of the enzymes the adrenal glands use to produce hormones that help regulate metabolism, the immune system, blood pressure and other essential functions. CAH affects the production of one or more of three steroid hormones: cortisol, which regulates your body's response to illness or stress; mineralocorticoids, such as aldosterone, which regulate sodium and potassium levels; or androgens, such as testosterone, which are sex hormones.

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